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The results demonstrated that luteolin significantly enhanced cell viability, diminished apoptosis, upregulated Bcl-2 expression, and downregulated Bax and caspase-3 levels

The studies tested various doses including 0.25 mg, 0.5 mg, and 1 mg daily via subcutaneous administration over periods ranging from single doses to 24 weeks of continuous therapy

Despite their benefits, weight gain, diabetes, metabolic syndrome, and cardiovascular disease are common side effects of this type of drugs, and insulin resistance that may be induced because of their use has been related to changes in DNA methylation, particularly with hypomethylation in fatty acyl CoA reductase 2 [246]

An Acad Bras Cienc 88:16551674 Brigelius-Floh R, Maiorino M (2013) Glutathione peroxidases

Zanella, A

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