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The copper ion is coordinated to the peptide through the nitrogen atoms of the glycine and histidine residues, giving the compound its distinctive blue color in crystalline form

Pain occurs two or three times more frequently in patients with PD than in individuals of similar age without PD 38 , 39 , 40

Angiogenesis refers to the creation of new blood vessels, which is an essential component of wound healing

AE collected articles and wrote the first draft of manuscript, JWG initiated the study and revised the manuscript and TLW finalized the manuscript

Together, this evidence suggests that while mutations or inadequacy of DNA repair mechanisms may play a role in promoting cancer neogenesis and progression, these deficiencies may increase sensitivity of cancer to therapy

Statements Author contributions SC and VT drafted the manuscript, read and approved the final manuscript, and are responsible for all aspects of the manuscript