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Similarly, topiramate decreased its MDA levels and increased GSH levels in a study on the prevention of flap necrosis after plastic and reconstructive surgery (Ahmadzadeh et al., 2022)

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[DOI] [PubMed] [Google Scholar] 4.Musaogullari A, Chai Y-C: Redox Regulation by Protein S-Glutathionylation: From Molecular Mechanisms to Implications in Health and Disease

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IC50 values (the concentration required to inhibit 50% of enzyme activity) for 5-Amino-1MQ against NNMT are in the low micromolar range (approximately 25 M in published in vitro assays), while IC50 values for structurally related methyltransferases are orders of magnitude higher, suggesting high specificity

Karkkainen J, Laitinen T, Markowicz-Piasecka M, Montaser A, Lehtonen M, Rautio J, Gynther M, Poso A, Huttunen KM