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Tesofensine is a powerful weight loss compound that inhibits the reuptake of dopamine, serotonin, and norepinephrine, effectively reducing appetite and food cravings

Indeed, while some estimates find that the development of new drugs might take around 1315 years with an overall investment of around US$ 1.33 billion to bring one drug to the market, it has been proposed that drug repurposing might allow to save 57 years, reduce the cost to around US$ 300 million per molecule, and the risk of failure from more than 95% for newly-designed drugs to around 45% for a repurposed one (Nosengo, 2016

Figg, Pharmacogenetics of membrane transporters: an update on current approaches,Molecular Biotechnology, vol

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J Clin Endocrinol Metab (2011) 96:E192533

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