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Today, with the rapid development of computational technology, MD simulation can not only study single proteins but also analyze complex protein-protein/DNA/RNA complexes (Norberg and Nilsson, 2003

4151-A UNMET SYSTEMIC THERAPY NEED FOR CHILD-PUGH CLASS B PATIENTS WITH UNRESECTABLE HEPATOCELLULAR CARCINOMA COMPARISON OF ATEZOLIZUMAB PLUS BEVACIZUMAB AND LENVATINIB Hideko Ohama 1,2,3 , Atsushi Hiraoka 1,2 , Toshifumi Tada 2 , Masashi Hirooka 2 , Kazuya Kariyama 2 , Ei Itobayashi 2 , Tsuji Kunihiko 2 , Toru Ishikawa 2 , Hidenori Toyoda 2 , Takeshi Hatanaka 2 , Satoru Kakizaki 2 , Atsushi Naganuma 2 , Tomomitsu Matono 2 , Fujimasa Tada 1,2 , Kazuhiro Nouso 2 , Yoichi Hiasa 2 and Takashi Kumada 2 , (1)Ehime Prefectural Central Hospital, (2)Relpec Study Group and HCC 48 Group, (3)Takarazuka City Hospital Background: Systemic treatment is generally recommended for unresectable hepatocellular carcinoma (uHCC) patients with Child-Pugh (CP)-A status

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NAFLD is becoming a major cause of liver-related morbidity worldwide, impacting nearly 25% of the global population, 10,11 and is typically associated with obesity, insulin resistance, diabetes, and dyslipidemia

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When any of these pathways are blocked, homocysteine levels can rise, which causes negative long-term health effects