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When methylation is under-fueled or bottlenecked, you feel it as low mood or drive, poor stress tolerance, slow recovery, brain fog, and disrupted sleep, and you often see it as elevated homocysteine

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Liu B, Luo C, Zheng Z, Xia Z, Zhang Q, Ke C, Liu R, Zhao Y (2018) Shengui Sansheng San extraction is an angiogenic switch via regulations of AKT/mTOR, ERK1/2 and Notch1 signal pathways after ischemic stroke

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