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310 Pro-inflammatory activation further disrupts the TCA cycle, leading to substrate accumulation (e.g., citrate, succinate, and aconitate)

For instance, one of the most studied polyphenols has been curcumin, gaining a lot of attention also for nutraceutical applications

Future research is necessary to scrutinize cellular and molecular mechanisms of action of AR in cancer cells and the tumour microenvironment, to develop selective modulators of AR activity, and to identify patients with non-prostatic cancer who might benefit from targeting this pathway