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They do not show that BPC-157 binds directly to FAK or that the same pathway controls every effect in every cell type

Indeed, microglial activation leads to increased production of cytokines and activation of nitric oxide synthases (iNOS)

Alternatively, it was suggested that the discrepancies in the presence of ROS would be explained by differences in the timepoints studied, in a scenario where oxidative stress would be a secondary effect rather than a primary cause, occurring later in the progression of FRDA (discussed in Lupoli et al., 2018)

L-glutathione inhibited NO production in a concentration-dependent inhibition (Fig

Paravar T, Lee DJ

Funding BDK and GDG are thankful to the Indian Council of Medical Research (ICMR), New Delhi, India for providing financial assistance in the form of ICMR- Adhoc Research Project