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J Proteome Sci

In a cancer setting, M1 macrophages generally promote inflammation and active antitumor immune responses

Evaluation of other naphthoquinones and juglone analogues against ChaC1 reveals plumbagin as a second inhibitor against ChaC1 The MD simulations suggested that the Juglone-GS conjugate formation was responsible for the inhibition of ChaC1 (and not juglone per se ) since other known mechanisms were eliminated

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These compounds have been studied for their immunomodulating, anti-inflammatory, neuroprotective, and anti-cancer properties