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In the United States, Novo Nordisk has a 40-year presence, is headquartered in New Jersey, and employs approximately 10,000 people across more than 10 manufacturing, R&D, and corporate locations in seven states plus Washington, D.C

Furthermore, the repressed expression of several subunits of the NADH dehydrogenase respiratory complex I, one of the main ROS producers in mitochondria, renders neurofibromin-deficient cells more resistant to pro-oxidant drugs acting through complex I-mediated ROS increase