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Activation of these pathways leads to the production of cytokines and the activation of various inflammation signaling pathways within the host (55).Although some moderate activation of the immune system will lead to increased therapeutic efficacy when used to modulate an individual's metabolic disease (14), excess activation or stimulation could lead to strong inflammatory response or worsening of autoimmune disease (39) (75).In addition, immune system responses could also be stimulated due to exposure to heterologous proteins produced by genetically engineered probiotics, such as GLP-1 analog, IL-10 (14) (19)

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Confocal images were acquired using a Zeiss LSM880 microscope with a 100 oil objective

Firstly, enhancing the pharmacokinetic properties of AS-IV through advanced drug delivery systems, such as nanocarriers or liposomal formulations, may improve its bioavailability and ensure more consistent therapeutic levels

[DOI] [PubMed] [Google Scholar] Matthew JB, Friend SH, Botelho LD, Lehman LD, Hanania GI, Gurd FRH