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Dongiovanni P, Stender S, Pietrelli A, Mancina RM, Cespiati A, Petta S, Pelusi S, Pingitore P, Badiali S, Maggioni M, et al

AP-1 plays a crucial role in the transcription regulation of MMP-1, MMP-3 and MMP-9, which progressively damage collagen (58)

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BPC157 has demonstrated an exceptional safety profile across multiple studies with no evidence of organ toxicity, mutagenicity, or carcinogenicity. Sikiric et al., Journal of Physiology and Pharmacology Long-Term Safety and Human Use Although human clinical trials are limited, the peptide has been used extensively in animal models and self-experimentation circles with no long-term complications reported

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