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Cell Metab (2020) 32:27386

160 SayinV

P38alpha MAPK signaling-a robust therapeutic target for Rab5-mediated neurodegenerative disease

Department of Biochemistry, University of Toronto, Ontario Cancer Institute, Canada

Vitamin D repletion resulted in a significant reduction in pain scores on both the VAS and MPQ at 48.5% and 39.4%, respectively

This movement combined with the change in charge introduced by the mutations modifies the binding cavity, forcing glutathione to adopt a nonproductive binding mode and permitting trypanothione and to a certain degree also the weak substrate glutathionylspermidine to assume a productive mode