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During the latter part of spermatogenesis, the chromatin material undergoes dramatic compaction, which renders spermatozoa transcriptionally silent, and cytoplasm is shed in the form of residual bodies (88)

The inactivation mechanism of low molecular weight phosphotyrosine-protein phosphatase by H 2 O 2

The resulting tissue damage involves multiple molecular mechanisms (205, 206)

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CCA subtyping has benefited from single-cell RNA sequencing, allowing, for instance, the definition of perihilar large duct-type and peripheral small duct-type iCCA and their associated biomarkers, S100P and SPP1, respectively 67

However, patients with dihydrobiopterin deficiency may develop early brain atrophy and intracranial perivascular calcifications [118, 119]