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These combinations lack standardized dosing and introduce variables that complicate research outcomes

Response: We appreciate the commenters' remarks as to the importance of maintaining the ability of the physician/NPP to make changes to a patient's POC outside of the 10-day window, as noted at 410.61(d), if we were to adopt this 10-day window policy

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Summary: Yes, vitamin B12 is a water-soluble vitamin that dissolves in water and is excreted through urine, though uniquely it can be stored in the liver for several years