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Abbreviations AD: Alzheimers disease ANS: Autonomic nervous system BBB: Blood brain barrier CNS: Central nervous system GABA: Gamma aminobutyric acid NF-B: Nuclear factor kappa B NLRP3: Nod-like receptor pyrin 3 PD: Parkinsons disease ROS: Reactive oxygen species SAH: S-adenosyl-homocysteine SN: Substantia nigra References Aborode AT, Pustake M, Awuah WA, Alwerdani M, Shah P, Yarlagadda R, Ahmad S, Silva Correia IF, Chandra A, Nansubuga EP, Abdul-Rahman T, Mehta A, Ali O, Amaka SO, Zuiga YMH, Shkodina AD, Inya OC, Shen B, Alexiou A (2022) Targeting oxidative stress mechanisms to treat alzheimers and parkinsons disease: a critical review

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Preclinical models demonstrate that these compounds reduce reactive oxygen species, stabilize mitochondrial membrane potential, enhance mitophagy, and activate NRF2 dependent transcription, which translates into attenuation of ASD like behaviors in VPA, propionic acid, maternal immune activation, and BTBR paradigms (Bambini Junior et al., 2014

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Ongoing Research Epithalon remains an active area of investigation across aging biology, molecular genetics, and regenerative research