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doi: 10.1002/bip.23025 34 OlsenM.SchadeS.LyonsS.AmaralM.SontheimerH

The Cys 36 residue in GpoA is encoded by a UGU codon, however, GpoA present a SECIS element identified in silico immediately after this codon that suggest an evolution from selenocysteine to cysteine in S

Discovery and optimization of tetrahydroacridine derivatives as a novel class of antibiotics against multidrug-resistant Gram-positive pathogens by targeting type I signal peptidase and disrupting bacterial membrane

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Mitochondrial mass assessed by NAO staining in ( a ) HCT116 cells treated with TS-targeting therapies, ( b ) non-small cell lung cancer (NSCLC) cell lines treated with pemetrexed, ( c ) HCT116 cells treated with 5FU, FOLFOX (5FU+oxaliplatin), FOLFIRI (5FU + SN38), or single agent oxaliplatin and SN38, or ( d ) HCT116 cells treated 5FU Torin or rapamycin for 72 h