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Typically, the concentration of carnitine in plasma is in the low M range (~4060), while tissue concentrations (taken here to approximate cytoplasmic concentrations) are in the low mM range (~15 mM) 26,27

PloS One (2012) 7(2):e32094

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The first step involves ligation of -glutamate to cysteine to form -glutamylcysteine, a reaction catalyzed by GCL

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d h , Quantification of PMA-induced NETs formation (100 nM, 6 h) in WT and XKR8-deficient neutrophils after pre-incubation with various inhibitors: Tempol (30 M) ( d , n = 12), DPI (10 M) ( e , n = 11), GSK2795039 (10 M) ( f , n = 12), Enzastaurin (10 M) ( g , n = 12), U0126 (10 M), GW5074 (10 M) ( h , n = 12)