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This gamma -ketoenal has been shown to bind covalently to mouse, rat, and human liver microsomes, and the binding parallels the hepatotoxicity of menthofuran in these species

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182 Additionally, aspirin improves the efficacy of gemcitabine by inhibiting the accumulation of myeloid-derived suppressor cells (MDSCs) and M2-polarized tumor-associated macrophages, both of which contribute to immune evasion and chemoresistance

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