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In preclinical studies, obese primates treated for eight weeks with the MC4R agonist RM-493 (Setmelanotide) lost an average of 13.5% of their body weight, with significant improvements in both insulin sensitivity and cardiovascular function

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A study involving 6,820 adults from the Midlife in the United States study found that poorer sleep health across multiple dimensions, including sleep regularity, alertness, timing, efficiency and duration, was associated with a higher risk of heart disease

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Relation of birth weight and childhood respiratory infection to adult lung function and death from chronic obstructive airways disease