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These models often fail to provide stable pathway signatures for specific phenotypes or reliable biomarkers of disease, hindering the creation of unbiased, data-driven networks for identifying biomarkers, targets, and diseases [118]

GSH is implicated in inducing autophagy, where low GSH levels serve as a signal activating autophagy as an adaptive stress response (101)

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Further, ketogenic diet-induced activation of HCA2 is known to deliver neuroprotective signals through noninflammatory macrophage infiltration to the ischemic brain