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Rapid plasma degradation and limited, variable BBB transport make systemic peripheral dosing of the parent peptide an inefficient route of exposure for any putative central target

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The mechanism underlying these cognitive improvements involves direct enhancement of synaptic connectivity

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Peptides can be modified in various ways, including functionalization of the N- and C-termini, derivatization of reactive groups in the 20 proteinogenic amino acids, and replacing specific amino acids with non-proteinogenic or unusual amino acids