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London: British Medical Association and Royal Pharmaceutical Society of Great Britain

In the event of an immediate adverse reaction during intravenous infusion, the administration of the drug should be interrupted immediately and, if possible, the unused remaining liquid should be saved for examination

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People with bipolar disorder (an illness characterized by mood swings, from depression to mania) should not take SAMe for their depressive symptoms except under the supervision of a health care provider because SAMe may worsen symptoms of mania

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