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reported that TQ at 80 mg/kg, but not 40 mg/kg, markedly caused chromosomal aberrations and DNA damage in the liver and kidney of BALB/c mice, indicating its genotoxic risk at high doses [331]

Sun, Y., Geng, W., Pan, Y., Wang, J., Xiao, P., & Wang, Y

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Bastian SE, Walton PE, Wallace JC, Ballard FJ. Plasma clearance and tissue distribution of labelled insulin-like growth factor-I (IGF-I) and an analogue LR3IGF-I in pregnant rats. J Endocrinol. 1993 Aug;138(2):327-36.doi: 10.1677/joe.0.1380327. PMID: 7693845

PubMed Central , Complementary Therapies in Medicine , vol

Research models show the combined GHRH+GHRP mechanism produces a synergistic GH pulse that neither molecule produces alone