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In case a serious adverse event would require the randomization code to be broken for a given participant, sealed opaque envelopes labelled with the randomization number and containing the associated supplements were prepared by the same unblinded individual, and kept at the clinical center

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Thus, only about 1% of GSH thiols will be deprotonated at any one moment in the cytosol (pH 7.2)

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The number of genes exhibiting different expression before versus after L-serine administration decreased from 20 to 16 under this alternative framework, but the majority of the molecular signature remained (Supplementary Fig