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In such situations the histogram frequently indicates burnt-out highlights (see the example on the right)

Asymmetric Unit Assembly Macromolecule Content Total Structure Weight: 20.49 kDa Atom Count: 1,439 Modeled Residue Count: 183 Deposited Residue Count: 183 Unique protein chains: 1 Macromolecules About About Us Citing Us Publications Team Careers Usage & Privacy Support Contact Us Help Website FAQ Glossary Service Status RCSB PDB is hosted by RCSB PDB is a member of RCSB Partners Nucleic Acid Knowledgebase wwPDB Partners RCSB PDB PDBe PDBj BMRB EMDB

It catalyzes de novo pyrimidine ribonucleotide synthesis, and cancer cells proliferate and require more nucleotides, hence it has been investigated researched as cancer treatment [69].Metabolomic profiling studies have demonstrated the involvement of DHODH and mito-GPX4 in scavenging reactive oxygen species (ROS) and their unique roles in inducing apoptosis, irrespective of their usual function in nucleotide synthesis [18, 70]

Ideta R, Sakuta T, Nakayama Y, Uchida C

Signaling molecules are delivered to the nucleus to activate the liver regeneration, including hepatocyte proliferation, stem cell differentiation, extracellular matrix remodeling, and termination signals that regulate the size of the regenerated liver

Sheik et al