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What they found: Oral AOD-9604 reduced body fat by 18 to 22 % vs placebo, comparable to injection administration No changes in total body weight (because lean mass rose slightly) Decrease in plasma triglycerides by 30 % Decrease in resting free fatty acids (paradoxically, mobilization of fat from depots into oxidation) No GI side effects Why it matters: It suggested that AOD-9604 could work orally , a rare property for a peptide

and McCarty M.F

RG supervised the study and edited the manuscript

it sits at the top of a hierarchy of clocks of various tissue and cell types that display independent circadian gene expression patterns that are entrained by neural and humoral signals from the SCN (Tosini and Menaker, 1996

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