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Front Neurol 12:769511 Niu YJ, Jiang ZM, Shu H, Li CF, Liu W, Yao GX, Jiang J, Li JQ, Longo A (2002) Assay of carnitine in plasma and urine of healthy adults

The animal study was approved by Animal Ethics Committee of Capital Medical University

added LC (0.3, 0.6 and 1.2 mg/mL) to culture media containing swamp buffalo oocytes and noted an improved nuclear maturation rate with a maximum number of metaphase II (MII) oocytes in the 0.3 mg/mL LC-supplemented group [66]

Based upon the data in the study, we propose that CVS is likely the result of cellular hyperexcitability, as a result of a vicious cycle of elevated intracellular cations and mitochondrial dysfunction (Figure 1)

D.et al (2020)

Estimated lifetime cardiovascular, kidney, and mortality benefits of combination treatment with SGLT2 inhibitors, GLP-1 receptor agonists, and nonsteroidal MRA compared with conventional care in patients with type 2 diabetes and albuminuria