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Catechol groups, inspired by mussels, undergo partial deprotonation and transformation into reactive o-dihydroxyphenyl groups under physiological conditions, which then interact via covalent and non-covalent bonds with amine, imidazole, and thiol groups on the biological matrix surface to achieve tissue adhesion (Waite et al., 2005

These conditions are also typified by loss of mitochondrial health through dysfunction of homeostatic components such as mitophagy, unfolded protein response, and the antioxidant system

Farnsworth A

Increased serum and brain concentrations of lactate, pyruvate, lactate/pyruvate ratio, alanine, and creatine kinase, at 31%, 14%, 28%, 8%, 47%, 35%, 46%, and 7%, respectively, and low carnitine were described in 90% of children with ASD in the review of Rossignol and Frye [38]

Experimental biology and medicine (Maywood, N.J)