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PMID: 35794518 Mol Biol RepThe investigation of glutamate transporter 1 (GLT-1) degradation pathway in glioblastoma cells

The first two categories are primarily driven by genetic mechanisms, while the third represents a non-genetic mechanism of resistance

Enhancing intrinsic neuronal resilience through pathways such as Nrf2ARE signaling, sirtuin activation, and the regulation of autophagy reflects a promising avenue grounded in the reinforcement of cellular homeostasis

doi: 10.1038/s41420-019-0214-2 419 GaoYWangSDangSHanSYunCWangWet al

In healthy brains, excitatory neurotransmitters like glutamate and inhibitory neurotransmitters such as GABA maintain a delicate balance that ensures proper neuronal function [137]

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