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Importantly, these AGE-induced alterations align with clinical observations of elevated AGE accumulation in the skin of FA patients 25 and epidemiological evidence linking high-AGE food consumption (e.g., fast food and fried/microwaved meat) with increased FA prevalence 26,27,28

[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Radford-Smith D.E., Yates A.G., Rizvi L., Anthony D.C., Probert F

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Since most ACDs are cytotoxic with a narrow therapeutic window, small blood concentration changes of drugs induced by herbal medicines are likely to produce profound alterations in efficacy or safety issues

In recent decade, clinical trials in UC have evolved (Table 1)

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