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Jiang W, Tang YY, Zhu WW, Li C, Zhang P, Li RQ, Chen YJ, Zou W, Tang XQ

38 Iron overload Although iron is a helpful component of the human body and the major micronutrient in the human diet, involved in crucial cellular functions and metabolic processes, excessive iron increases the production of ROS, leading to cell dysfunction or death, tissue damage, and organ disease

Ideal maintenance candidates include: People on plant-based diets who need regular B12 supplementation to prevent gradual depletion

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While H 2 O 2 did not directly contribute to polyamine-induced cell death under our experimental conditions, polyamines have previously been shown to enhance cellular sensitivity to RSL3-induced ferroptosis through H 2 O 2 generation 46

[Google Scholar] 36.Biewenga G.P., Haenen G.R., Bast A