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PMID: 26099365

This approach has led to one of the early programmes for inhaled insulin and eventually to FDA-approved inhaled l-DOPA for the treatment of Parkinson disease 106,107

Its optimized 3PO derivative, PFK158, showed enhanced tolerability and reduced glycolytic flux in preclinical studies, was selected as the first-in-human, first-in-class PFKFB3 inhibitor, and has entered phase I clinical trials for advanced solid malignancies [256]

24 The incidence of Grade 3 or higher liver injury during ICI therapy was significantly higher in patients with viral hepatitis compared to those without (28% vs

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