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Major Urinary Protein Urokinase-Type Plasminogen Activator Model A relatively new NASH model has been developed by transiently upregulating ER stress in the liver by delivering major urinary protein urokinase plasminogen activator ( MUP-uPA ) into the hepatocytes via adeno associated virus coupled with a HFD (Nakagawa et al., 2014

Despite its dry, inflammatory nature, PsO does not spread through contagion

Celastrol-loaded enzyme-responsive nanoparticles dually target osteoclasts and inflammatory macrophages derived from patients with RA, leading to increased apoptosis of these cells

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As the disease progresses, macrophages can shift toward the M2 phenotype, contributing to tissue repair and fibrosis