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First, T1-weighted anatomical MRI images were collected using 3D-MPRAGE sequences (192 slices, voxel size 1 mm 3 , FOV = 256 256 176 mm, TR = 2,250 ms, TE = 2.6 ms, FA = 9), and resliced into axial and coronal views to allow more precise and consistent placement of the MRS voxels of interest

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Bleomycin-induced mouse fibrosis model and administration of anti-CD38 antibodies All animal studies were conducted in accordance with NIH guidelines for the care and use of laboratory animals and animal protocols were institutionally approved by the Animal Care and Use Committees of Northwestern University and the University of Michigan