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Increased risk of bleeding, ulcers, and tears (perforation) of the esophagus (tube leading from the mouth to the stomach), stomach and intestines: o anytime during use o without warning symptoms o that may cause death The risk of getting an ulcer or bleeding increases with: o past history of stomach ulcers, or stomach or intestinal bleeding with use of NSAIDs o taking medicines called "corticosteroids","anticoagulants", "SSRIs", or "SNRIs" o increasing doses of NSAIDs o longer use of NSAIDs o smoking o drinking alcohol o older age o poor health o advanced liver disease o bleeding problems NSAID medicines should only be used: o exactly as prescribed o at the lowest dose possible for your treatment o for the shortest time needed What are Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?NSAIDs are used to treat pain and redness, swelling, and heat (inflammation) from medical conditions such as different types of arthritis, menstrual cramps, and other types of short-term pain

doi: 10.1146/annurev-arplant-042811-105524 124 TsukagoshiH

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Unfortunately, even despite standard method guidelines outlined more than 20 years ago (CROSERF