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For the proper delivery of the drug encapsulated in the liposome, it is imperative to take into consideration the properties of both the stratum corneum and the drug, while considering the site of application, body temperature, and the blood flow of the skin

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In this study of FM/chronic fatigue syndrome, patients who were good responders were found to be using a higher and more frequent doses of vitamin B12 for a longer period [17]

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Kuwana M, Medsger TA Jr, Wright TM (1995) T cell proliferative response induced by DNA topoisomerase I in patients with systemic sclerosis and healthy donors