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R f 0.60 (petroleum ether-EtOAc 9:1)

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Personalized Diagnoses for Those Born with Congenitally Malformed Hearts

doi: 10.1053/j.gastro.2009.05.044 6

GOT2-mediated aKG production is critical for maintaining the cFLIP level Gln is first converted into glutamate (Glu) by glutaminase, which is localized in mitochondria 28 , and mitochondrial Glu is subsequently converted into aKG by Glu dehydrogenase 1 (GLUD1) or by transaminases, including glutamic-oxaloacetic transaminase 2 (GOT2) 29 (Fig