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As our understanding of the beneficial attributes of bioactive components in stroke continues to grow, it is likely that bioactive components interventions will play an increasingly important role in the comprehensive management of this devastating condition

SAMe is an allosteric activator of cystathionine--synthase (CBS) ( MAT1A expression (Figure 3)

5-amino-1-methylquinolinium, commonly known as 5 Amino 1 MQ, is a drug that inhibits the enzyme called nicotinamide N-methyltransferase (NNMT)

58 These cell-intrinsic changes in epithelial cells have also been shown to promote the occurrence of OSF by maintaining the activation of some key profibrotic pathways

doi: 10.1017/S0007114513000548 93

Te Kronnie, G