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Stress due to imbalances in O 2 /CO 2 supply and oxidative species Hypoxia O 2 stress Hypoxia, inadequate oxygen supply, is a common stressor that cells face during fetal development, upon environmental variations such as high altitudes, and during pathological conditions like myocardial or cerebral ischemia, and in cancer (see Oncogenic signaling) where hypoxia is very common in solid tumors [73]