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For in vitro binding of mSIN with RICTOR, equal amounts of the purified GST or GST-mSIN proteins immobilized to glutathione sepharose TM 4B beads were incubated with purified SFB-RICTOR either in the presence of recombinant His-PTPN22 or equal volume of corresponding buffer for 1 h at 4 C

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Research in APP/PS1 Alzheimer's mice demonstrates that Dihexa treatment markedly reduces activation of astrocytes and microglia, the brain's primary inflammatory cells

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