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For example, Papokastas and colleagues 5 found that treatment of major depressive disorder (MDD) with 15mg of Lmethylfolate in conjunction with an SSRI showed significantly greater efficacy compared to SSRI therapy alone regarding response rate and degree of change in depression symptom scores

[DOI] [PMC free article] [PubMed] [Google Scholar] 86.Carrier E.J., Auchampach J.A., Hillard C.J

Combined with the results of multiple survival analysis, such as overall survival and meta-survival, GSTM3/4 could augment drug metabolism to blunt the effects of chemotherapy drugs, leading to poor prognosis for OC patients

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Not only does it make everyday activities difficult, but it can also lead to a reduced quality of life