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Ketosis and Disease Ketosis is a state wherein the body cannot get energy from circulating glucose , so it turns to fats as a primary energy source instead

In this process, ingested Cys is catalyzed by thioredoxin reductase 1 (TrxR1) to convert it to Cys, which is then combined with glutamic acid (Glu) through the catalytic action of GLU Cys ligase (GCL) to form -glutacyl-L-Cys

Together, these results indicate that PS-MPs affect neurological function via the lungbrain axis, representing an important mechanism underlying PS-MPs-induced cognitive impairment ( Microplastics can cross the bloodbrain barrier, impairing the functions of neuroinflammatory secretion, transporter proteins, and receptor markers, thereby causing neurological damage and subsequently triggering various brain disorders ( The accumulation of polystyrene nanoplastics leads to increased levels of amyloid- (A) and phosphorylated Tau protein (P-Tau) in the cerebral cortex and hippocampus, which are metabolic waste products associated with neurobehavioral disorders and neurodegenerative diseases such as Alzheimers disease

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5.5 Metabolic regulation therapy Metabolic modulation therapy has demonstrated potential therapeutic value for a variety of diseases, including RA, by regulating cellular metabolic pathways, improving cellular energy metabolism under hypoxic conditions and reducing metabolic stress responses

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