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Signs and symptoms of vitamin B12 deficiency signs may include: Weakness or fatigue Pale skin Appetite loss Weight loss Palpitations Numbness and tingling Poor concentration Infertility Depression Memory impairment Sore mouth or tongue Disturbed sleep Frequent infections What are the side effects of a B12 shot

Heart palpitations or increased heart rate

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Repeat every 23 months in severely deficient areas, or every 56 months where deficiency is mild