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This type typically develops in the mid-lung zone and periphery of the lung

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Instead Grx2, a mitochondrial isoform, exhibits de-glutathionylation activity for peptides and proteins but with a catalytic activity 10-fold lower with respect to Grx1 ( S -glutathionylation can be catalyzed by glutathione- S -transferase P (GSTP)

Significant patient heterogeneity in baseline oxidative stress levels, comorbidities, and genetic predispositions further complicates a one-size-fits-all approach, influencing individual responses to targeted therapies (Zou et al., 2024)

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