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This is because it takes time for the glutathione levels to build up in the tissues and for new skin cells to cycle through

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Cheon et al., 2023)

The nucleoside reverse transcriptase inhibitor (NRTI) antiretroviral drug class for instance, is known to cause depletion of mitochondrial DNA via inhibition of the mitochondrial specific DNA polymerase-

[DOI] [PMC free article] [PubMed] [Google Scholar] Grady D, Herrington D, Bittner V, Blumenthal R, Davidson M, Hlatky M, Hsia J, Hulley S, Herd A, Khan S, Newby LK, Waters D, Vittinghoff E, Wenger N

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