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(PubMed) Pledgie-Tracy A, Sobolewski MD, Davidson NE

Focused ultrasound therapy (FUS) is another method used to facilitate transport through the BBB

doi: 10.1038/cdd.2014.137 33 SeibtTMPronethBConradM

& Amores-Snchez, M

G.AryalB.Canfrn-DuqueA.GoldbergE

We selected pAcF as the handles for constructing conjugates instead of other chemistry such as azide mediated click chemistry as the cyclopropane-tetrazine ligation employed in the pAcF system demonstrates superior bioorthogonality compared to azide-alkyne cycloadditions, effectively minimizing off-target reactions in complex cellular environments