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Geneva: World Health Organization, 1186

The L-cystine dependent mechanism described here, in addition to findings that GLUT1 is commonly upregulated in GBM 71 , suggests that a synthetic lethal approach targeting GSH synthesis and GLUT1 activity may result in selective toxicity towards cancer cells

Page 137 and 138: 52

In contrast, high light (2,500 mol m 2 s 1 ) decreased GSH content in Golden Agave ( Agave Americana L.) leaves after 2 h (Deng, Malus spp .) after 3 h (Davey et al., 2 s 1 ) in cucumber ( Cucumis sativus L.) leaves (Jiang et al., 2013)

To investigate the mechanisms involved, macrophage-specific HIF1-knockout or FXR agonist-treatment in DSS-PN mice both showed increased expression of STAT6 target genes compared to DSS-PN