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The Phase 3 OPTIONS study (536 subjects, 24 weeks) failed to show statistically significant weight loss compared to placebo

B12 Deficiency and Weight Gain: What You Should Know Feeling sluggish, gaining unexplained weight, or finding it hard to stay motivated

No participants withdrew from any trial due to tolerability issues, indicating that even when side effects occurred, they were sufficiently manageable that participants chose to continue treatment

Low Energy and Fatigue If fatigue is your primary struggle, this may be where you notice the most significant improvement

Mitochondrial Pathways

Unlike others, the absorption of vitamin B12 depends on a protein called intrinsic factor, which is produced in the stomach