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Metabolic acidosis and hemolytic anemia have been associated with low levels of glutathione

doi: 10.3390/ijms24010755 16 UllahAUd DinADingWShiZPervazSShenB

Thus, elevated levels or activity of these mediators might provide an explanation for CD38 upregulation noted in SSc skin biopsies 24

Most studies involve small sample sizes, short durations, or lack control groups, which hampers the ability to draw definitive conclusions

278 ZhuL.ShanH.ChenS.JiangJ.GuC.ZhouG.et al

In the Comprehensive Medical Chemistry database, approximately 7000 drugs have been evaluated, with only 5% of them being able to cross the BBB and enter the CNS [295]